Dimethyltryptamine (DMT): a biochemical Swiss Army knife in neuroinflammation and neuroprotection?

The hallucinogen N,N-dimethyltryptamine (DMT) is an endogenous sigma-1 receptor regulator.

The sigma-1 receptor is widely distributed in the central nervous system and periphery. Originally mischaracterized as an opioid receptor, the sigma-1 receptor binds a vast number of synthetic compounds but does not bind opioid peptides; it is currently considered an orphan receptor. The sigma-1 receptor pharmacophore includes an alkylamine core, also found in the endogenous compound N,N-dimeth...

Effects of iproniazid and tranylcypromine of the half-life of N,N-dimethyltryptamine in rat brain and liver.

The time course of N.N-dimethyltryptamine (DMT) levels in brain and liver of adult male Holtzman rats was determined with and without pretreatment with the monoamine oxidase inhibitors iproniazid (32 mg/kg) and tranylcypromine (IO mg/kg) given i.p. DMT was given in doses of 1.0. 3.2 and 10.0 mg/kg i.p. DMT was assayed spectrophotofluorometrically and in some Instances by a radioisotopic method....

RESEARCH Phenomenology of N,N-Dimethyltryptamine Use: A Thematic Analysis

N,N-dimethyltryptamine (DMT) is an endogenous hallucinogenic compound in the same chemical class as the more common psilocybin and the neurotransmitter serotonin. Despite previous experimental research assessing the subjective effects of DMT (e.g., Strassman et al., 1994), no qualitative studies have been conducted. Consequently, 19 DMT users were asked to provide thorough descriptions of the s...

Risk assessment of ritual use of oral dimethyltryptamine (DMT) and harmala alkaloids.

AIM To extend previous reviews by assessing the acute systemic toxicity and psychological hazards of a dimethyltryptamine and beta-carboline brew (ayahuasca/hoasca) used in religious ceremonies. METHOD A systematic literature search, supplemented by interviews with ceremony participants. RESULTS No laboratory animal models were located that tested the acute toxicity or the abuse potential o...

Multipurpose Identity-Based Sign ryption A Swiss Army Knife for Identity-Based Cryptography